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Lara K Leister Selected Research

Ulcerative Colitis

1/2019Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
1/2017Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

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Lara K Leister Research Topics

Disease

2Ulcerative Colitis
01/2019 - 01/2017
2Rheumatoid Arthritis
01/2019 - 01/2017
2Psoriasis (Pustulosis Palmaris et Plantaris)
01/2019 - 01/2017
2Pain (Aches)
09/2009 - 10/2008
1Pancreatic Neoplasms (Pancreatic Cancer)
06/2019
1Adenocarcinoma
06/2019
1Neoplasms (Cancer)
06/2019
1Alzheimer Disease (Alzheimer's Disease)
01/2019
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2019
1Inflammation (Inflammations)
01/2019

Drug/Important Bio-Agent (IBA)

2Phosphotransferases (Kinase)IBA
06/2019 - 01/2019
2N,N- diethyl- 4- (5- hydroxyspiro(chromene- 2,4'- piperidine)- 4- yl)benzamideIBA
09/2009 - 10/2008
2delta Opioid Receptors (delta Opioid Receptor)IBA
09/2009 - 10/2008
2piperidineIBA
09/2009 - 10/2008
2BenzopyransIBA
09/2009 - 10/2008
2benzamideIBA
09/2009 - 10/2008
1A-Form DNA (A-DNA)IBA
01/2017
1Anti-Inflammatory Agents (Anti-Inflammatories)IBA
01/2017
1CytokinesIBA
01/2017
1GSK2982772IBA
01/2017
1N,N- diethyl- 3- hydroxy- 4- (spiro(chromene- 2,4'- piperidine)- 4- yl)benzamideIBA
09/2009
1compound 20IBA
10/2008

Therapy/Procedure

1Therapeutics
06/2019